Toodles hires detectives Tom and Jerry to investigate and protect her against a threat to her Tuna can inheritance. They go investigate, and a mysterious and menacing figure keeps trying to hurt them.
When Tom ruins Hildie and Beatie’s potions, they get fed up with him and he overhears them wanting a black cat instead of him. He makes and drinks a potion that turns him into a black cat, and they assume he’s another cat.
Tom is assigned to guard his owner’s garden of crops against pests, including Jerry and a clan of harvest mice who all resemble him (albeit with different-colored bandanas).
Rick and Ginger go on a road trip to visit Ginger’s great aunt Claire, but on the trip, Spike and Tom get lost, and Spike deals with “The Doggie of Doom” who follows them.
Both Tom and Butch compete against to go after Ginger’s mom’s bird when her and Rick watch it for the weekend. Jerry also makes sure nothing happens to the bird.
When Jerry and Tuffy are planning to go on a vacation, Jerry gets mailed away when Tuffy forgets to bring a camera along with them, so Tuffy stays home and outwits Tom while Jerry attempts to come back home.
After accidentally trashing a fancy hotel lobby during another chase against Jerry, Tom is hired as a bellboy by the hotel’s manager in order to pay for the damages. Unfortunately, Jerry makes Tom’s assignments difficult.
When Jerry ventures out of his hole for a late night snack, Tom has a trap set for him. Unfortunately for Tom, he falls into his own trap and gets his head stuck through the wall and into Jerry’s house. Jerry tries everything he can to dislodge Tom, and almost gives up hope of ever […]
While celebrating the holidays with Beatie and Hildie, Tom and Jerry destroy their Christmas tree and must go out to obtain a new one. In the process, they help out Santa Claus by delivering presents for Christmas.
When a burglar has been breaking in homes, Rick and Ginger leave Spike in charge and Spike teaches Tom and Jerry how to protect their home and defend themselves.
Detectives Tom and Jerry are hired by Polly the Dog to get back her collar from mean Barkley at the park. After a series of incidents involving the pound “jail” and an electric fence, Barkley reforms when he meets Polly and falls in love with her.
At a laboratory, Jerry, using a virtual reality setup, plays a game in which Tom is hated by Mrs. Two-Shoes (while she likes Jerry) and is scared of Jerry. When Tom arrives at the laboratory, he plays a game in which Spike is scared of him (albeit still talking while Tom still does not).
A sequel to Pecos Pest (1955), Jerry’s uncle, Pecos Pest, returns to Tom and Jerry’s house for a visit, where he constantly sings and plays on his guitar, annoying and keeping both Tom and Jerry awake.
Nancy, Tom’s owner from Baby Puss (1943), brings Tom to her elementary school for show-and-tell in which she wants Tom to win the gold star for best pet.
