Peter Parker / Spider-Man discovers that his science teacher, Dr. Curt Connors, has been turned into a deranged lizard due to an experiment gone wrong, and is abducting people throughout Manhattan.

Norman Osborn hires Spencer Smythe to capture Spider-Man. Spencer creates his deadliest weapon, the Spider Slayer, to accomplish this, but he seemingly dies at the end of this episode in an explosion.

Wilson Fisk, also known as the Kingpin, offers to provide Alistair Smythe with the funds he requires to build more of Spencer’s Spider-Slayer robots, claiming that Spider-Man is responsible for the death of his father. Alistair fails in his bid to kill Spider-Man and the others he holds responsible for his father’s death, and as […]

When Peter arrives for a date with Felicia Hardy, she is kidnapped by corrupt scientist Doctor Octopus, in order to force her mother to provide him with ransom money in which she promised to fund his experiments. Complicating things, Peter recognizes the madman as Otto Octavius, his favorite science mentor from his childhood days.

J. Jonah Jameson and many others believe that Spider-Man is responsible for robberies that have been happening recently. Peter thus decides to search for clues to prove that these robberies were caused by a Spider-Man imposter. He teams up with Detective Lt. Terry Lee and confronts Mysterio, a self-proclaimed master of the mystic arts.

Mac Gargan, a small-time crook hired by Jameson to follow Peter and find out how he is able to get pictures of Spider-Man, strikes a deal with Jameson to eliminate Spider-Man. Gargan is taken to the lab of Dr. Farley Stillwell, where he is transformed into the supervillain Scorpion.

As Peter goes to an interview with scientist Mariah Crawford, she is under attack by the villain Kraven the Hunter. After Spider-Man is able to elude him, Dr. Crawford explains that Kraven and her used to be in love but when he was seriously injured by lions she had no choice but to give him […]

Astronauts John Jameson and Paul Stevens are sent to a newly discovered asteroid and discover a rock, known as “Promethium X”, which is said to be more powerful than plutonium. Unknown to them though, the “Promethium X” also contains a black, ooze-like creature, which manages to break free and tries to consume the two astronauts. […]

Peter, with his powers enhanced by his new suit, focuses his attention on Brock and Jameson and warns the latter to call off his reward, also mentioning Rhino and how Brock neglected to mention him. Jameson finds out from John that Brock was lying and fires him. He also calls off the manhunt for Spider-Man. […]

Peter, returned to his old costume, soon comes across the Rhino and the Shocker, who manage to get the upper hand on him. However, an unknown “ally” arrives and defeats the two villains himself. The new “ally” is Brock, now known as Venom, who has bound to the discarded symbiote and wants revenge on Spider-Man.

Osborn hires the Hobgoblin to assassinate Kingpin, because of the crime lord’s continuous threats against him. Peter saves Kingpin just as the Hobgoblin attempts an attack on him. After eluding Spider-Man, the Hobgoblin is fired by Osborn as of his unsuccessful assassination on Kingpin.

The Hobgoblin defeats Wilson Fisk and declares himself the new Kingpin of Crime. Fisk then asks Osborn to assist him in reclaiming his position.

The Chameleon, an international spy, attempts assassination on two diplomats in order to derail the signing of a peace proposal. S.H.I.E.L.D. director Nick Fury enlists Jameson’s help to prevent the Chameleon’s crime, while Spider-Man begins his own hunt against the assassin.

Kingpin hires Rhino, Shocker, Doctor Octopus, Mysterio, Scorpion and the Chameleon to take down Spider-Man. Meanwhile, Peter has been experiencing brief periods of time where his powers temporarily vanish.

Spider-Man walks into the trap of the supervillains, calling themselves the Insidious Six, at a warehouse. Spider-Man attempts to battle the six, but is captured and unmasked, although he manages to convince the supervillains that he is a fraud. Meanwhile, Dr. Connors reveals that Spider-Man has begun to mutate further, which is the cause of […]

While dealing with the stunning revelation of his condition, Spider-Man finds himself dealing with the rash of mysterious robberies happening across town. As Peter, he tries to get closer to Mary Jane Watson, and discovers that she is being stalked by an ex-boyfriend who reveals himself to be the super-thief Hydro-Man, who is obsessed at […]

Spider-Man begins to worry about his growing mutation. In order to seek a cure, he heads to the Xavier mansion, where he encounters the X-Men. A brief fight occurs, after which Spider-Man explains his plight to Charles Xavier, who tells Spider-Man that he cannot cure him. Beast tells Spider-Man to go to Herbert Landon, who […]

Wolverine catches up with Spider-Man, who is hot on the trail of the missing Beast. Meanwhile, the Hobgoblin steals the mutant technology information that Landon had prepared for Kingpin. Meanwhile, Genevieve, Landon’s assistant, struggles with keeping her secret of being a telekinetic mutant, who saved Spider-Man from the collapsing ceiling.

Crawford has developed a cure for Spider-Man’s disease, but she is reluctant to give an untested serum to him that may result in permanent loss of his powers or worse. After an angry outburst from Spider-Man, she hands it over. At the ESU lab, Peter is secretly observed by Felicia’s latest love interest, Michael Morbius, […]

An increasingly desperate Spider-Man drinks the serum designed to cure him, but it makes him grow four extra arms. The antihero known as the Punisher thinks Spider-Man is a crook and chases him around. Spider-Man finds out that Morbius has turned into a vampire and is draining people’s blood to survive. Spider-Man wants to help […]

Spider-Man’s horrifying genetic mutation reaches its culmination as he transforms into the Man-Spider. Dr. Crawford summons Kraven to help her track down Spider-Man and cure him of his mutation with a newly developed antidote.

The vampire hunter Blade arrives in New York City to destroy Morbius, but Spider-Man wants to revert Morbius back into his human form.

Spider-Man and Blade put aside their differences in an attempt to prevent Morbius from using the Neogenic Recombinator to transform everyone into vampires like himself. They team up with Lt. Lee, who falls for Blade. During one attempt to stop Morbius, he kidnaps Peter’s aunt May and Felicia, causing Spider-Man and Blade to have a […]

An ancient artifact known as the Tablet of Time has been uncovered. Kingpin wants to sell it, while elderly Silvermane wants to use it to restore his youth. Each crime lord kidnaps a useful hostage and a useless hostage.

With the Tablet of Time, Silvermane’s youth is restored, but he continues to grow younger until he finally becomes an infant. Surprisingly, the Tablet is also able to revert the Lizard back to Dr. Connors. As the ordeal has caused his wife Vanessa Fisk to leave him, Kingpin orders the Tablet gotten rid of which […]

When Osborn attempts to take over Toomes Aeronautical, Toomes becomes furious. He uses the Tablet of Time technology to steal youth from anyone he touches, becoming the Vulture to destroy Osborn.

Spider-Man seeks Dr. Connors’ aid to help reverse the aging effects of the Vulture’s talons. After absorbing Spider-Man’s youth and DNA, the Vulture mutates into the Man-Spider. Meanwhile, the Scorpion grabs Dr. Stillwell to seek a cure for his own mutation.

Mary Jane has joined a cult under the control of Baron Mordo, being led to believe that she has a relationship with her father. As Spider-Man investigates the truth behind the cult’s intentions, he has a meeting with Doctor Strange and Wong and aids them in preventing Mordo from unleashing his dread master Dormammu from […]

In a battle with Doctor Octopus, a medical research building is destroyed. Blaming himself, Peter is considering giving up being Spider-Man, when he meets an inter-dimensional being named Madame Web and his biggest fan, a little girl called Taina, who Spider-Man shares his origin story with. Doctor Octopus attacks with his new invention, the Octobot.

During Spider-Man’s battle with Octobot, Doctor Octopus uses a nerve nullifying blaster to give Spider-Man amnesia, convincing him that he is his personal assistant and goes on a crime spree. Taina manages to get Spider-Man to remember his true self; he then returns her back to her room, where he even reveals his true identity […]

While developing a new gas for Kingpin to use as a weapon, a mistake triggers an explosion and Osborn disappears in the chaos. A new villain, the Green Goblin, appears and kidnaps all of Osborn’s enemies. Felicia later meets with Spider-Man, tells him that she is in love with him, and passionately kisses him.

Spider-Man tells Felicia that he can’t have a girlfriend. She understands this, but wants Spider-Man to know how she feels about him. Meanwhile, Jackson Weele leads a gang of thieves armed with jet-pack technology. Weele has developed a large gyro-wheel in which he uses to plunge through the city. Peter wants to ask Felicia to […]