Spike and his girlfriend Toodles mistake Tom and Jerry for valets, as a result of which upon leaving their car to be parked while checking themselves in a hotel, Tom and Jerry unwillingly go on a wild and elaborate joyride across town.
At a zoo, an artistic monkey paints Tom to look like a tiger after he accidentally wrecks his art during a chase against Jerry. As a result, Tom manages to scare Jerry as well as everyone else and every animal at the zoo with his tiger look.
Nancy, Tom’s owner from Baby Puss (1943), brings Tom to her elementary school for show-and-tell in which she wants Tom to win the gold star for best pet.
A sequel to Pecos Pest (1955), Jerry’s uncle, Pecos Pest, returns to Tom and Jerry’s house for a visit, where he constantly sings and plays on his guitar, annoying and keeping both Tom and Jerry awake.
Tom seeks to catch and eat Jerry, the star of the show at a local ocean theme park along with a bald eagle, but he is then thwarted by another eagle, a seal and an octopus.
Tom is assigned to guard his owner’s garden of crops against pests, including Jerry and a clan of harvest mice who all resemble him (albeit with different-colored bandanas).