A sequel to Pecos Pest (1955), Jerry’s uncle, Pecos Pest, returns to Tom and Jerry’s house for a visit, where he constantly sings and plays on his guitar, annoying and keeping both Tom and Jerry awake.
Tom gets Spike sent to obedience school for being naughty, and Jerry is left without a protector. When Spike returns, Tom tries hard to get Spike to revert to his old ways. Jerry fights back to make sure that Spike keeps his cool.
At a laboratory, Jerry, using a virtual reality setup, plays a game in which Tom is hated by Mrs. Two-Shoes (while she likes Jerry) and is scared of Jerry. When Tom arrives at the laboratory, he plays a game in which Spike is scared of him (albeit still talking while Tom still does not).
Dr. Bigby upgrades his robot to be “The future of home security,” but when Tom invades the lab to pursue Jerry and Napoleon, the robot has some tricks up its sleeves which will lead the robot into hysteria.
After the plane incident, Rick and Ginger sneak Tom and Spike at “Paradise Resort” where pets are not allowed, but when Rick and Ginger leave Tom and Spike in their room, Jerry and Tuffy cause them trouble.
Rick and Ginger go on a road trip to visit Ginger’s great aunt Claire, but on the trip, Spike and Tom get lost, and Spike deals with “The Doggie of Doom” who follows them.
When Jerry and Tuffy are planning to go on a vacation, Jerry gets mailed away when Tuffy forgets to bring a camera along with them, so Tuffy stays home and outwits Tom while Jerry attempts to come back home.
Both Tom and Butch compete against to go after Ginger’s mom’s bird when her and Rick watch it for the weekend. Jerry also makes sure nothing happens to the bird.
Spike and his girlfriend Toodles mistake Tom and Jerry for valets, as a result of which upon leaving their car to be parked while checking themselves in a hotel, Tom and Jerry unwillingly go on a wild and elaborate joyride across town.
When Tom ruins Hildie and Beatie’s potions, they get fed up with him and he overhears them wanting a black cat instead of him. He makes and drinks a potion that turns him into a black cat, and they assume he’s another cat.
After accidentally trashing a fancy hotel lobby during another chase against Jerry, Tom is hired as a bellboy by the hotel’s manager in order to pay for the damages. Unfortunately, Jerry makes Tom’s assignments difficult.
Nancy, Tom’s owner from Baby Puss (1943), brings Tom to her elementary school for show-and-tell in which she wants Tom to win the gold star for best pet.
