When Dexter is bitten by a clown’s dentures, he begins turning into a mad clown every night, terrorizing the town with his mayhem, and only Dee Dee, who knows mime, can stop him.
Dexter and Mandark bring the Abraham Lincoln and George Washington faces respectively on Mount Rushmore to life and make them fight each other to determine who is the best.
After a crime prevention talk at school, Dee Dee, Lee Lee, and Mee Mee become crime fighters, but they unintentionally end up being neighborhood criminals.
Not interested in hearing Dee Dee’s long-winded story, Dexter gives her a silencing formula to keep her quiet, but it instead turns her into a giant monster still bent on telling her story. When he realizes that nothing can make her quiet, he becomes a giant monster himself.
After Dexter’s pencil rolls to the back of the school bus, Dexter goes to retrieve it, but legend says that no one has ever returned from the back of the bus.
Monkey must defend the city from a giant underground lava monster, Magmanamus (Brad Garrett), who cannot sleep because of the noise created by its residents.
After Dexter orders and eats a giant burrito, he suffers severe stomach pains. Believing a test the computer gave him, he assumes that he has only 30 minutes to live.
When Dexter’s friends become tired of his complicated traps and cheating while playing a role-playing game, they put Dee Dee in his place. She changes the style of play, which annoys Dexter but impresses his friends.
Dexter, Monkey, Agent Honeydew, the Justice Friends, Dee Dee, her imaginary friend Koosalagoopagoop, Mandark, his parents, and Dexter’s parents participate in a cross-country race a la Wacky Races.
Mandark brings his lab duck Ducky for show and tell to counter Dexter and his lab monkey. Though neither creature displays remarkable characteristics at school, Ducky, unbeknownst to Mandark, is the alter ego of supervillain Quackor the Fowl.