When an electrician comes to Dexter’s house to repair a blown-out fuse, he accidentally stumbles onto his laboratory, and Dexter enlists him to repair the lab.
Dexter is disappointed when he ends up at an Amish farm instead of a high-tech farm for summer camp. His attempts to modernize the Amish family do not go well.
Dee Dee and her friends, Lee Lee and Mee Mee, enter Dexter’s lab and wreak havoc. Dexter clones himself to stop them, but the girls too make clones of themselves.
Dexter finds a lost Labrador Retriever, but when he teaches the dog to speak human language, he turns out to be very annoying, prompting Dexter to find the dog’s owner.
After fellow Justice Friend White Tiger helps Valhallen stop a super-villain, the latter invites him to spend the night in his apartment, forgetting that Major Glory is allergic to cats.
Dexter reluctantly takes piano lessons from Professor Williams (Paul Williams), but when the Professor stumbles onto Dexter’s lab, he discovers that Dexter has more musical talent than he thought.
When Dexter’s friends become tired of his complicated traps and cheating while playing a role-playing game, they put Dee Dee in his place. She changes the style of play, which annoys Dexter but impresses his friends.
Dexter is forced to take Dee Dee to the zoo. There, she ends up trying to save an ostrich with disastrous results. Dee Dee and the ostrich switches their places.
Mandark disguises himself as Dexter’s mom to get into Dexter’s Lab. Unfortunately for Mandark, he now has to deal with Dexter, Dad, and Dee Dee’s requests, which are too much for him.
When his family is suffering from the flu, Dexter tries his best to not acquire the illness, but his efforts are thwarted by a sick Dee Dee’s presence in his lab.
Monkey must defend the city from a giant underground lava monster, Magmanamus (Brad Garrett), who cannot sleep because of the noise created by its residents.
Dexter’s school and parents decide to send him to college. He ignores his fellow students, who prefer to “party now, study later”, until his mind finally snaps from the workload.