When he tries out a new cheese-in-a-can that Rick and Ginger buy, Tom has a crazy day when he experiences hallucinations based on the show’s other scenarios.
Upon seeing Tom unable to catch Jerry, Butch recruits the former to join the League of Cats, a secret organization of cats who work together to catch mice.
While celebrating the holidays with Beatie and Hildie, Tom and Jerry destroy their Christmas tree and must go out to obtain a new one. In the process, they help out Santa Claus by delivering presents for Christmas.
Tom is assigned to guard his owner’s garden of crops against pests, including Jerry and a clan of harvest mice who all resemble him (albeit with different-colored bandanas).
Spike and his girlfriend Toodles mistake Tom and Jerry for valets, as a result of which upon leaving their car to be parked while checking themselves in a hotel, Tom and Jerry unwillingly go on a wild and elaborate joyride across town.
Detectives Tom and Jerry are hired by Polly the Dog to get back her collar from mean Barkley at the park. After a series of incidents involving the pound “jail” and an electric fence, Barkley reforms when he meets Polly and falls in love with her.
When Tom ruins Hildie and Beatie’s potions, they get fed up with him and he overhears them wanting a black cat instead of him. He makes and drinks a potion that turns him into a black cat, and they assume he’s another cat.
Dr. Bigby creates cookies that give super strength and Jerry and Napoleon eat them and they have fun terrorizing Tom. He eventually gets revenge on them, however.