Jerry and his friend Napoleon are lab mice and Tom is outside going through trash until he sees the two mice that he wants for an appetite and things go crazy when Dr. Bigby’s elderly cat becomes a vicious kitten and chases the mice.
Ginger gets a high-tech mattress and Tom is forbidden to sleep on it, but when Butch sees it and tries it out, it results in him, Tom, and Jerry fighting over the bed.
Dr. Bigby upgrades his robot to be “The future of home security,” but when Tom invades the lab to pursue Jerry and Napoleon, the robot has some tricks up its sleeves which will lead the robot into hysteria.
Tom gets Spike sent to obedience school for being naughty, and Jerry is left without a protector. When Spike returns, Tom tries hard to get Spike to revert to his old ways. Jerry fights back to make sure that Spike keeps his cool.
Detectives Tom and Jerry discover Butch and a squirrel are stealing their business and later discover they are con artists and are stealing from customers.
Nancy, Tom’s owner from Baby Puss (1943), brings Tom to her elementary school for show-and-tell in which she wants Tom to win the gold star for best pet.
Little Quacker enlists Jerry’s help in getting his cracked favorite birdbath fixed, but they get distracted by the smell of Tom’s delicious Chinese takeout. After fighting over the food, Tom steals Little Quacker’s fortune cookie and gets the kind of fortune he deserves.
Tom has a date with Toodles and she warns him not to be late, but Butch tricks Tom that Toodles has a surprise in the basement for him and he leaves him down there; Toodles leaves Butch in charge of her younger, rowdy siblings; Jerry and Tuffy watches a horror movie and mistakes Tom for […]
Upon seeing Tom unable to catch Jerry, Butch recruits the former to join the League of Cats, a secret organization of cats who work together to catch mice.