When his family is suffering from the flu, Dexter tries his best to not acquire the illness, but his efforts are thwarted by a sick Dee Dee’s presence in his lab.
Dee Dee accidentally shuts down Dexter’s lab, and he has to power it back. In the process, Dee Dee attempts to keep Dexter from finding out what she really did.
To learn more about girls, Dexter camouflages himself and enters Dee Dee’s room, where she is having a sleepover with her friends Lee Lee and Mee Mee. He gets caught by the girls, who force him to take part in their activities.
Mandark disguises himself as Dexter’s mom to get into Dexter’s Lab. Unfortunately for Mandark, he now has to deal with Dexter, Dad, and Dee Dee’s requests, which are too much for him.
When Dexter is asked to bring his mother to school, he disguises Dee Dee as her so that she can take her place, but Dee Dee does not behave like their mother.
Dexter, Monkey, Agent Honeydew, the Justice Friends, Dee Dee, her imaginary friend Koosalagoopagoop, Mandark, his parents, and Dexter’s parents participate in a cross-country race a la Wacky Races.
Suspicious that Dee Dee has not entered his lab even once on a particular day, Dexter shrinks himself and enters her room to spy on her. He soon becomes an unwilling character in Dee Dee’s doll story, but he believes the story to be real.
Loading the player... During a trip to Japan as part of a student exchange program, Dexter accidentally releases a giant monster with an axe-like head from a volcano, forcing him to enlist the aid of his family to defeat it.
Dexter finds a lost Labrador Retriever, but when he teaches the dog to speak human language, he turns out to be very annoying, prompting Dexter to find the dog’s owner.
Dexter is forced to take Dee Dee to the zoo. There, she ends up trying to save an ostrich with disastrous results. Dee Dee and the ostrich switches their places.
Dexter and Dee Dee listen in on their parents’ conversation; they are playing Scrabble, but the way they talk makes it sound like Dad was cheating on Mom