In need of an assistant to operate his latest invention, Dexter performs a brain transplant on Dee Dee to make her smart enough to fulfill the role. With her new brain, Dee Dee proves to be more intelligent than Dexter.
When Dexter tries to inject himself into an ill Dee Dee to find a cure to the common cold, he accidentally ends up inside his dog, believing that Dee Dee is infected with a dog virus.
Dexter finds the exact opposite of his family, a hyperactive boy who is like Dee Dee and has scientist parents who are like Dexter. Sensing to fit in, he switches places with the boy.
It is Career Day, and because Dexter is ashamed of his father, he creates a better father for himself. However, he soon discovers that his real father is much cooler.
Loading the player... Dexter decides to work with Mandark, but finds himself doing all of the work. In the end, Mandark tries to press the button when Dexter connects the plug in the outlet to bring his show title back.
Dexter’s father sleepwalks into Dexter’s lab. Dexter discovers this, and now has to escort him out of the lab without waking him up, which proves more difficult than thought.
Dexter’s new device allows him to study for the next day’s French test while sleeping. It malfunctions, causing a single phrase (omelette du fromage) to repeat throughout the night, causing Dexter to wake up the next morning speaking nothing else except omelette du fromage.
On his birthday, Dexter makes himself invisible so that he can find out whether his parents have bought him the Major Glory action figure he always wanted.
Dexter, Monkey, Agent Honeydew, the Justice Friends, Dee Dee, her imaginary friend Koosalagoopagoop, Mandark, his parents, and Dexter’s parents participate in a cross-country race a la Wacky Races.
After a crime prevention talk at school, Dee Dee, Lee Lee, and Mee Mee become crime fighters, but they unintentionally end up being neighborhood criminals.
Dexter and Dee Dee’s father buys a video game for them to play, but the game sucks Dexter inside when he plugs in the cartridge, and it is up to Dee Dee to bring him out.
Dee Dee’s stuffed animals come to life and roam the house when Dee Dee uses a formula that brings inanimate objects to life, which delights Dee Dee, much to his dismay.
Dee Dee dares Dexter into building her a giant robot similar to his Robo-Dexo 2000. They then team up to try to save an island’s population from being destroyed by an erupting volcano using their giant robots.
Mandark Astronomanov, a new student at Dexter’s school, seems to be superior to Dexter academically. Mandark forces Dexter to shut down his lab so that Mandark’s lab can gain more power. However, with the help of Dee Dee, Dexter manages to destroy Mandark’s lab.
Dee Dee and her friends, Lee Lee and Mee Mee, enter Dexter’s lab and wreak havoc. Dexter clones himself to stop them, but the girls too make clones of themselves.
