It is Career Day, and because Dexter is ashamed of his father, he creates a better father for himself. However, he soon discovers that his real father is much cooler.
Mandark Astronomanov, a new student at Dexter’s school, seems to be superior to Dexter academically. Mandark forces Dexter to shut down his lab so that Mandark’s lab can gain more power. However, with the help of Dee Dee, Dexter manages to destroy Mandark’s lab.
Suspicious that Dee Dee has not entered his lab even once on a particular day, Dexter shrinks himself and enters her room to spy on her. He soon becomes an unwilling character in Dee Dee’s doll story, but he believes the story to be real.
Since his studying is interrupting his favorite TV shows, Dexter creates a helmet to absorb the shows directly. However, the plan backfires when he randomly snaps into television-based outrages.
When Dexter is bitten by a clown’s dentures, he begins turning into a mad clown every night, terrorizing the town with his mayhem, and only Dee Dee, who knows mime, can stop him.
Dexter reluctantly takes piano lessons from Professor Williams (Paul Williams), but when the Professor stumbles onto Dexter’s lab, he discovers that Dexter has more musical talent than he thought.
When Dexter tries to inject himself into an ill Dee Dee to find a cure to the common cold, he accidentally ends up inside his dog, believing that Dee Dee is infected with a dog virus.
Mandark brings his lab duck Ducky for show and tell to counter Dexter and his lab monkey. Though neither creature displays remarkable characteristics at school, Ducky, unbeknownst to Mandark, is the alter ego of supervillain Quackor the Fowl.