In a battle with Doctor Octopus, a medical research building is destroyed. Blaming himself, Peter is considering giving up being Spider-Man, when he meets an inter-dimensional being named Madame Web and his biggest fan, a little girl called Taina, who Spider-Man shares his origin story with. Doctor Octopus attacks with his new invention, the Octobot.

Spider-Man seeks Dr. Connors’ aid to help reverse the aging effects of the Vulture’s talons. After absorbing Spider-Man’s youth and DNA, the Vulture mutates into the Man-Spider. Meanwhile, the Scorpion grabs Dr. Stillwell to seek a cure for his own mutation.

While dealing with the stunning revelation of his condition, Spider-Man finds himself dealing with the rash of mysterious robberies happening across town. As Peter, he tries to get closer to Mary Jane Watson, and discovers that she is being stalked by an ex-boyfriend who reveals himself to be the super-thief Hydro-Man, who is obsessed at […]

Peter Parker / Spider-Man discovers that his science teacher, Dr. Curt Connors, has been turned into a deranged lizard due to an experiment gone wrong, and is abducting people throughout Manhattan.

Norman Osborn returns as the Green Goblin where he and the Hobgoblin, whom he considers an imposter, clash over Ohn’s time dilation accelerator. Meanwhile, Felicia is engaged to a smug playboy of whom Peter is greatly suspicious of.

With the Tablet of Time, Silvermane’s youth is restored, but he continues to grow younger until he finally becomes an infant. Surprisingly, the Tablet is also able to revert the Lizard back to Dr. Connors. As the ordeal has caused his wife Vanessa Fisk to leave him, Kingpin orders the Tablet gotten rid of which […]

Astronauts John Jameson and Paul Stevens are sent to a newly discovered asteroid and discover a rock, known as “Promethium X”, which is said to be more powerful than plutonium. Unknown to them though, the “Promethium X” also contains a black, ooze-like creature, which manages to break free and tries to consume the two astronauts. […]

The Chameleon, an international spy, attempts assassination on two diplomats in order to derail the signing of a peace proposal. S.H.I.E.L.D. director Nick Fury enlists Jameson’s help to prevent the Chameleon’s crime, while Spider-Man begins his own hunt against the assassin.

Spider-Man begins to worry about his growing mutation. In order to seek a cure, he heads to the Xavier mansion, where he encounters the X-Men. A brief fight occurs, after which Spider-Man explains his plight to Charles Xavier, who tells Spider-Man that he cannot cure him. Beast tells Spider-Man to go to Herbert Landon, who […]

Trapped in the limbo between portals, the Green Goblin telepathically calls out to his son, Harry Osborn. Keeping his true identity a secret, he promises Harry that he will see his father soon if he becomes the second Green Goblin. Meanwhile, thinking Peter knows where Mary Jane is, Anna Watson unknowingly passes this information to […]

The mutated Morbius is found by scientists and taken back to New York to have his condition studied. The Shocker kidnaps Morbius for Dr. Landon, who manages to revert Morbius back to his previous vampire form; however, in the confusion, Morbius escapes while Spider-Man fights his foes.

During Spider-Man’s battle with Octobot, Doctor Octopus uses a nerve nullifying blaster to give Spider-Man amnesia, convincing him that he is his personal assistant and goes on a crime spree. Taina manages to get Spider-Man to remember his true self; he then returns her back to her room, where he even reveals his true identity […]

Spider-Man and the Black Cat attempt to confront Kraven. After the latter eludes the two heroes, there are various reports of attacks. Debra Whitman decides to investigate and she, Black Cat, Flash Thompson, and Dr. Connors succeed in identifying the DNA as female. It turns out that Dr. Crawford had been given the same serum […]

Dr. Jonathon Ohn is a brilliant scientist who created the time dilation accelerator portal-making machine for Tony Stark. However, following the battle against Venom and Carnage, Stark shut down the accelerator. Ohn is then approached by Kingpin, who funds Ohn’s research to have him continue the accelerator project, while Ohn falls in love with his […]

Norman Osborn hires Spencer Smythe to capture Spider-Man. Spencer creates his deadliest weapon, the Spider Slayer, to accomplish this, but he seemingly dies at the end of this episode in an explosion.

Doctor Octopus and Alistair join forces with the Red Skull. Spider-Man brings Black Cat to the planet to help him just as she, Morbius, and Blade were battling Miriam and her vampires. The team cross a wasteland in order to launch an assault on the Red Skull’s empire. Later, Spider-Man and Black Cat share a […]

Angry over his son’s arrest and conviction, as well as Spider-Man now knowing his secret identity, to which he blames Alistair, Kingpin attempts to kill Spider-Man by turning Alistair into a cyborg to let him do it. Alistair’s father, Spencer, is revealed to have survived the explosion from the first season, but Kingpin has put […]

Spider-Man grieves over Mary Jane’s loss following his battle against the Green Goblin. Meanwhile, Tombstone, whilst incarcerated in Ryker’s Island, plots revenge on Robbie for previously causing his arrest. In exchange for assisting cell-mate Richard Fisk in a few brawls in prison, Richard requests that his father frame Robbie as a criminal mastermind.

Spider-Man and Silver Sable track down Kragov, the Chameleon, and the Red Skull, but are caught in a force field. Apparently, the Doomsday Device the Skull created in the past was made to have Kravog turn into a “god”, being injected with electricity which allows him to create and manipulate electricity into doing his bidding. […]

Madame Web brings Spider-Man to another dimension where he is brought before a being known as the Beyonder, who has chosen Spider-Man to be part of an experiment to see if good is more powerful than evil. He finds a paradise planet and chooses Doctor Octopus, Doctor Doom, Alistair, the Lizard, and the Red Skull […]

Peter is framed by Kingpin’s son Richard Fisk and the Chameleon for selling government secrets to foreign organizations. Peter meets with Matt Murdock, a blind but talented Defense Attorney who secretly masquerades as the vigilante Daredevil.