Spike develops allergies and Rick thinks that Spike is likely allergic to Tom, so Rick gets a hypoallergenic kitten named Glory for Ginger; Spike, Tom and Jerry plan to get rid of the nice kitten who is actually anything but and will do whatever it takes to be an only pet.

Ginger and Rick decide to bring Tom and Spike along on their Hawaiian vacation, but on their plane flight, Jerry and Tuffy tag along as well. Tom and Spike get loose out of their cages, and before long, things go awry.

When an injured Tom sees a female cat named Misty across the street get catnapped, him and Jerry seeks help from her dog friend, Scarf to locate her.

When Hildie and Beatie go away on a vacation, Tom and Jerry has problems when their ghost nephew, Grayson, comes over and throws a large party with his friends and takes their crystal ball for bowling.

One of Dr. Bigby’s inventions make Tom intelligent.

When Tom ruins Hildie and Beatie’s potions, they get fed up with him and he overhears them wanting a black cat instead of him. He makes and drinks a potion that turns him into a black cat, and they assume he’s another cat.

Tom stars in a documentary that mis-characterizes his daily activities from chasing Jerry to “romancing” Toodles and messing with Spike.

The witch sisters both commemorate the passing of their mother and Tom tries to help out by bringing her back from the grave.

With eight of his nine lives gone, Tom uses magic in order to bring them back.

When Ginger’s wedding ring falls down the drain, Tom, Jerry and Spike have to get it back before she finds out.

Dr. Bigby creates cookies that give super strength and Jerry and Napoleon eat them and they have fun terrorizing Tom. He eventually gets revenge on them, however.

When Hildie gets a magic mirror that predicts the future, Tom sees predictions of himself being fed a fish, which is good, and then a bad prediction: switching heads with Beatie.

Spike forces Tom and Jerry to take over Tyke’s birthday party after they ruin it.

Both Tom and Butch compete for the Golden Fez in the United Mouse Catchers when they both attempt to capture Jerry.

Both Tom and Butch compete against to go after Ginger’s mom’s bird when her and Rick watch it for the weekend. Jerry also makes sure nothing happens to the bird.

Tom is under strict orders to not wake the witch sisters, but Jerry is set on getting Tom in trouble. When Tom uses the magic spell wand and makes all of the furniture come alive, he must get the help of Newt to make everything go back as it was.

Rick and Ginger’s vacation continues on a cruise ship, where to make sure Tom and Spike don’t cause havoc, they keep them in the carriers. Jerry and Tuffy invade their vacation again, and Meathead, the ship’s cat, hunts down Jerry and Tuffy on the ship.