Cow and Chicken are feeling down, and visit their next door neighbor, who happens to be a famous blues musician. Through song, he tells them a wild tale.
Chicken wakes up one morning to find that he is molting. He soon uses this to his advantage when he learns that he can get paid for all the feathers he loses.
Cow, Chicken and their cousin Boneless Chicken travel to the Lava Park, where they learn how to fly a kite. Unfortunately, when Baron Von Non-Leiderhosen (the Red Guy) loses his kite, he uses Boneless as one for a tug o’ war contest.
Cow has started taking up ballet, but due to her weight, she brings the house down (literally). Fortunately, she finds someone to help her find fame, in the form of homewrecker Mr. Slacksoff (the Red Guy).
Grandmama takes Cow and Chicken over to a mall, where they attempt to find a Grampa. While this old-timer is blind as a bat, Chicken uses this to his advantage in order to spend time with best buddies, Flem and Earl.
The school revamps their newspaper into a television news show with the help of Geraldo Rearviewa (the Red Guy), who uses Chicken to generate scandalous stories.
While trying out the Pork Butt catapult, Chicken is accidentally swallowed by Cow. Mom and Dad take her to a doctor (the Red Guy), and they must get Chicken back out before he journeys through all four of Cow’s stomachs.
Cow has become the most popular student in school thanks to her new glasses. Jealous of this, Chicken decides to get some as well, leading up to an attempt to destroy a new school dungeon (which was actually a new swimming pool).
Series finale, based on the novel I Am Legend. Weasel, I.R. and The Red Guy are believed to be the last beings on Earth, until they discover that everybody has been watching their show… where it turns out that Baboon is really the star!
As part of a school assignment, Cow and Chicken write essays on what jobs they want when they’re older. Since Cow’s essay won, she gets to live her dream as an astronaut, whereas the runner-up, Chicken, works at a supermarket
Chicken’s wish for Cow to shut up comes true. When he is run over by a truck, he regrets it after being sentenced to 50 years in prison for jaywalking (although the truck driver was at fault) when Cow refuses to clear his name.