On his birthday, Dexter makes himself invisible so that he can find out whether his parents have bought him the Major Glory action figure he always wanted.
The U.S. army invades Dexter’s lab under the mistaken impression that aliens are using it as a base of operations on Earth, and Dexter must convince them that this is actually his lab, and also has to keep this a secret from Dee Dee.
Dee Dee’s stuffed animals come to life and roam the house when Dee Dee uses a formula that brings inanimate objects to life, which delights Dee Dee, much to his dismay.
Dexter makes his own Major Glory action figures so that he can join the neighborhood’s Major Glory gang, but gets into serious trouble when the rest of the gang finds out that none of his action figures are original.
In need of an assistant to operate his latest invention, Dexter performs a brain transplant on Dee Dee to make her smart enough to fulfill the role. With her new brain, Dee Dee proves to be more intelligent than Dexter.
Dexter creates a new type of ink that lets him command people to do whatever he wants. However, when Mandark gets his hands on it, Dexter is the one that becomes commanded.
Dexter thinks that a crazy homeless person balancing electronic devices on his head and muttering gibberish is a genius trying to contact aliens, so he takes him home.
Dexter is forced to take Dee Dee to the zoo. There, she ends up trying to save an ostrich with disastrous results. Dee Dee and the ostrich switches their places.
Mandark brings his lab duck Ducky for show and tell to counter Dexter and his lab monkey. Though neither creature displays remarkable characteristics at school, Ducky, unbeknownst to Mandark, is the alter ego of supervillain Quackor the Fowl.
Dexter invents a robot parrot that happily repeats self-congratulatory comments he makes, but when it starts repeating things about his lab and escapes, he sets out to destroy it before it tattles to his parents.