Peter is framed by Kingpin’s son Richard Fisk and the Chameleon for selling government secrets to foreign organizations. Peter meets with Matt Murdock, a blind but talented Defense Attorney who secretly masquerades as the vigilante Daredevil.

Mary Jane is revealed to have new found water-based powers like Hydro-Man. Spider-Man follows Hydro-Man to an underwater lab, where he discovers that scientist Miles Warren has used his controversial cloning technology to create a clone of the original Hydro-Man. He is even more shocked to learn that Warren then used a drop from Hydro-Man […]

The mutated Morbius is found by scientists and taken back to New York to have his condition studied. The Shocker kidnaps Morbius for Dr. Landon, who manages to revert Morbius back to his previous vampire form; however, in the confusion, Morbius escapes while Spider-Man fights his foes.

Spider-Man’s horrifying genetic mutation reaches its culmination as he transforms into the Man-Spider. Dr. Crawford summons Kraven to help her track down Spider-Man and cure him of his mutation with a newly developed antidote.

Peter and Mary Jane arrive in Niagara Falls for their postponed honeymoon, but it is soon interrupted when Hydro-Man returns and kidnaps Mary Jane. With Black Cat’s help, Spider-Man sets off in pursuit.

Spider-Man walks into the trap of the supervillains, calling themselves the Insidious Six, at a warehouse. Spider-Man attempts to battle the six, but is captured and unmasked, although he manages to convince the supervillains that he is a fraud. Meanwhile, Dr. Connors reveals that Spider-Man has begun to mutate further, which is the cause of […]

Peter proposes to Mary Jane and she accepts, much to Anna’s discomfort. Peter and Mary Jane ask Dr. Connors to give her away at the wedding, when they are interrupted by three giant lizards who claim Connors is their father and kidnap him and Mary Jane. They are taken down to sewer, with Spider-Man in […]

In Moscow, Silver Sable surprises Doctor Grotizick. In America, Keane Marlow surprisingly visits May, who introduces him to her nephew, Peter, explaining Keane was an old friend of his uncle Ben. Peter finds his parents’ old passports. He subsequently shows them to May, who orders Peter to put them away. Peter, however, eavesdrops on his […]

Astronauts John Jameson and Paul Stevens are sent to a newly discovered asteroid and discover a rock, known as “Promethium X”, which is said to be more powerful than plutonium. Unknown to them though, the “Promethium X” also contains a black, ooze-like creature, which manages to break free and tries to consume the two astronauts. […]

Spider-Man is taken to an alternate dimension where due to a series of events, its native Peter has bonded with the Carnage symbiote to become the maniacal Spider-Carnage, who has devastated and demolished New York City with the aid of Kingpin, Alistair, the Hobgoblin, and the Green Goblin. The Beyonder tells Spider-Man that his deranged […]

Angry over his son’s arrest and conviction, as well as Spider-Man now knowing his secret identity, to which he blames Alistair, Kingpin attempts to kill Spider-Man by turning Alistair into a cyborg to let him do it. Alistair’s father, Spencer, is revealed to have survived the explosion from the first season, but Kingpin has put […]

Spider-Man and Daredevil attempt to clear Peter’s name. Daredevil informs Spider-Man of Wilson Fisk’s true identity as the Kingpin. As Spider-Man battles the Chameleon, the stage is set for a fateful showdown between Daredevil and Kingpin.

Wolverine catches up with Spider-Man, who is hot on the trail of the missing Beast. Meanwhile, the Hobgoblin steals the mutant technology information that Landon had prepared for Kingpin. Meanwhile, Genevieve, Landon’s assistant, struggles with keeping her secret of being a telekinetic mutant, who saved Spider-Man from the collapsing ceiling.

Spider-Man grieves over Mary Jane’s loss following his battle against the Green Goblin. Meanwhile, Tombstone, whilst incarcerated in Ryker’s Island, plots revenge on Robbie for previously causing his arrest. In exchange for assisting cell-mate Richard Fisk in a few brawls in prison, Richard requests that his father frame Robbie as a criminal mastermind.

Mac Gargan, a small-time crook hired by Jameson to follow Peter and find out how he is able to get pictures of Spider-Man, strikes a deal with Jameson to eliminate Spider-Man. Gargan is taken to the lab of Dr. Farley Stillwell, where he is transformed into the supervillain Scorpion.

The vampire hunter Blade arrives in New York City to destroy Morbius, but Spider-Man wants to revert Morbius back into his human form.

After a brief fight with Mysterio, Peter learns that Mary Jane finally got her big break in recreating the film role made famous by actress Miranda Wilson. However, it was a trap set by Miranda, who had survived the accident on the filming of her movie; Mysterio had taken on his supervillain identity to gather […]

Peter and Mary Jane are ready to tie the knot. Their plans are interrupted, however, when the Scorpion kidnaps May. Spider-Man gives chase and rescues May, but wonders if the fates are trying to tell him something. Meanwhile, Kingpin is paying for Peter and Mary Jane’s wedding. When the wedding finally takes place, a still […]

Spider-Man seeks Dr. Connors’ aid to help reverse the aging effects of the Vulture’s talons. After absorbing Spider-Man’s youth and DNA, the Vulture mutates into the Man-Spider. Meanwhile, the Scorpion grabs Dr. Stillwell to seek a cure for his own mutation.