While developing a new gas for Kingpin to use as a weapon, a mistake triggers an explosion and Osborn disappears in the chaos. A new villain, the Green Goblin, appears and kidnaps all of Osborn’s enemies. Felicia later meets with Spider-Man, tells him that she is in love with him, and passionately kisses him.

When the crime lord Iceberg finds out that one of his gang members, Hobie, doesn’t feel that he is getting a fair cut, he has his boys attempt to kill him. After narrowly escaping that fate, Hobie steals a passer-by’s purse in order to fund his new trip. It turns out to be Mary Jane’s […]

Spider-Man’s horrifying genetic mutation reaches its culmination as he transforms into the Man-Spider. Dr. Crawford summons Kraven to help her track down Spider-Man and cure him of his mutation with a newly developed antidote.

Spider-Man tells Felicia that he can’t have a girlfriend. She understands this, but wants Spider-Man to know how she feels about him. Meanwhile, Jackson Weele leads a gang of thieves armed with jet-pack technology. Weele has developed a large gyro-wheel in which he uses to plunge through the city. Peter wants to ask Felicia to […]

While dealing with the stunning revelation of his condition, Spider-Man finds himself dealing with the rash of mysterious robberies happening across town. As Peter, he tries to get closer to Mary Jane Watson, and discovers that she is being stalked by an ex-boyfriend who reveals himself to be the super-thief Hydro-Man, who is obsessed at […]

Spider-Man and the Black Cat attempt to confront Kraven. After the latter eludes the two heroes, there are various reports of attacks. Debra Whitman decides to investigate and she, Black Cat, Flash Thompson, and Dr. Connors succeed in identifying the DNA as female. It turns out that Dr. Crawford had been given the same serum […]

After a confrontation with Miriam the Vampire Queen, Blade is horrified to learn that she was once his human mother. Using a psychic link, Miriam finds Morbius, who is fighting his vampire hunger, to find out what unconventional means he used to become one of her kind. Learning of the Neogenic Recombinator, Miriam plans to […]

Trapped in the limbo between portals, the Green Goblin telepathically calls out to his son, Harry Osborn. Keeping his true identity a secret, he promises Harry that he will see his father soon if he becomes the second Green Goblin. Meanwhile, thinking Peter knows where Mary Jane is, Anna Watson unknowingly passes this information to […]

Mary Jane is revealed to have new found water-based powers like Hydro-Man. Spider-Man follows Hydro-Man to an underwater lab, where he discovers that scientist Miles Warren has used his controversial cloning technology to create a clone of the original Hydro-Man. He is even more shocked to learn that Warren then used a drop from Hydro-Man […]

Tombstone is hired by Silvermane’s daughter Alisa to destroy the story planned for the Daily Bugle revealing that she had taken over her father’s criminal organization. Tombstone attempts to use Robbie Robertson, whom he was childhood friends with, to kill the story, using Robbie’s teenage son Randy to do it.

Wilson Fisk, also known as the Kingpin, offers to provide Alistair Smythe with the funds he requires to build more of Spencer’s Spider-Slayer robots, claiming that Spider-Man is responsible for the death of his father. Alistair fails in his bid to kill Spider-Man and the others he holds responsible for his father’s death, and as […]

Spider-Man is able to rescue Robbie and escape the explosion. The following day, Peter and Robbie visit Robbie’s friend Russian police officer Boris Pushkin who claims to have known Peter’s parents. Chief of Police Rhienholdt Kragov interrupts and threatens that Peter and Robbie will be arrested if they don’t leave. Boris gave Robbie Doctor Grotizick’s […]

Wolverine catches up with Spider-Man, who is hot on the trail of the missing Beast. Meanwhile, the Hobgoblin steals the mutant technology information that Landon had prepared for Kingpin. Meanwhile, Genevieve, Landon’s assistant, struggles with keeping her secret of being a telekinetic mutant, who saved Spider-Man from the collapsing ceiling.

When Peter arrives for a date with Felicia Hardy, she is kidnapped by corrupt scientist Doctor Octopus, in order to force her mother to provide him with ransom money in which she promised to fund his experiments. Complicating things, Peter recognizes the madman as Otto Octavius, his favorite science mentor from his childhood days.

Spider-Man begins to worry about his growing mutation. In order to seek a cure, he heads to the Xavier mansion, where he encounters the X-Men. A brief fight occurs, after which Spider-Man explains his plight to Charles Xavier, who tells Spider-Man that he cannot cure him. Beast tells Spider-Man to go to Herbert Landon, who […]

Spider-Man walks into the trap of the supervillains, calling themselves the Insidious Six, at a warehouse. Spider-Man attempts to battle the six, but is captured and unmasked, although he manages to convince the supervillains that he is a fraud. Meanwhile, Dr. Connors reveals that Spider-Man has begun to mutate further, which is the cause of […]

As former sidekick of the late Black Marvel, Omar had hidden the Black Marvel’s keys after his death. Now aware of the Insidious Six’s theft of the majority of the keys, he was sure that they would search for them. Omar shows Robbie where the last keys are hidden. However, it unfolds to be the […]

The Hobgoblin defeats Wilson Fisk and declares himself the new Kingpin of Crime. Fisk then asks Osborn to assist him in reclaiming his position.

With the Tablet of Time, Silvermane’s youth is restored, but he continues to grow younger until he finally becomes an infant. Surprisingly, the Tablet is also able to revert the Lizard back to Dr. Connors. As the ordeal has caused his wife Vanessa Fisk to leave him, Kingpin orders the Tablet gotten rid of which […]

Kingpin and Doctor Octopus blackmail John Hardesky into revealing Captain America’s secret super-soldier formula by making threats against Felicia. After Hardesky reveals his secrets, Landon is able to recreate and improve the formula for Kingpin. He uses the serum to transform Felicia into a “black cat”, and forces her to carry out his crimes until […]

Spider-Man seeks Dr. Connors’ aid to help reverse the aging effects of the Vulture’s talons. After absorbing Spider-Man’s youth and DNA, the Vulture mutates into the Man-Spider. Meanwhile, the Scorpion grabs Dr. Stillwell to seek a cure for his own mutation.

Crawford has developed a cure for Spider-Man’s disease, but she is reluctant to give an untested serum to him that may result in permanent loss of his powers or worse. After an angry outburst from Spider-Man, she hands it over. At the ESU lab, Peter is secretly observed by Felicia’s latest love interest, Michael Morbius, […]

Spider-Man and Daredevil attempt to clear Peter’s name. Daredevil informs Spider-Man of Wilson Fisk’s true identity as the Kingpin. As Spider-Man battles the Chameleon, the stage is set for a fateful showdown between Daredevil and Kingpin.

When Osborn attempts to take over Toomes Aeronautical, Toomes becomes furious. He uses the Tablet of Time technology to steal youth from anyone he touches, becoming the Vulture to destroy Osborn.

Peter and Mary Jane arrive in Niagara Falls for their postponed honeymoon, but it is soon interrupted when Hydro-Man returns and kidnaps Mary Jane. With Black Cat’s help, Spider-Man sets off in pursuit.

J. Jonah Jameson and many others believe that Spider-Man is responsible for robberies that have been happening recently. Peter thus decides to search for clues to prove that these robberies were caused by a Spider-Man imposter. He teams up with Detective Lt. Terry Lee and confronts Mysterio, a self-proclaimed master of the mystic arts.

Peter Parker / Spider-Man discovers that his science teacher, Dr. Curt Connors, has been turned into a deranged lizard due to an experiment gone wrong, and is abducting people throughout Manhattan.

Angry over his son’s arrest and conviction, as well as Spider-Man now knowing his secret identity, to which he blames Alistair, Kingpin attempts to kill Spider-Man by turning Alistair into a cyborg to let him do it. Alistair’s father, Spencer, is revealed to have survived the explosion from the first season, but Kingpin has put […]

Kingpin hires Rhino, Shocker, Doctor Octopus, Mysterio, Scorpion and the Chameleon to take down Spider-Man. Meanwhile, Peter has been experiencing brief periods of time where his powers temporarily vanish.

During Spider-Man’s battle with Octobot, Doctor Octopus uses a nerve nullifying blaster to give Spider-Man amnesia, convincing him that he is his personal assistant and goes on a crime spree. Taina manages to get Spider-Man to remember his true self; he then returns her back to her room, where he even reveals his true identity […]

Peter, returned to his old costume, soon comes across the Rhino and the Shocker, who manage to get the upper hand on him. However, an unknown “ally” arrives and defeats the two villains himself. The new “ally” is Brock, now known as Venom, who has bound to the discarded symbiote and wants revenge on Spider-Man.

In Moscow, Silver Sable surprises Doctor Grotizick. In America, Keane Marlow surprisingly visits May, who introduces him to her nephew, Peter, explaining Keane was an old friend of his uncle Ben. Peter finds his parents’ old passports. He subsequently shows them to May, who orders Peter to put them away. Peter, however, eavesdrops on his […]