Following the break-up of Mystery Incorporated, the gang decides to move on with their lives by taking a weekend to check out a nearby university, but they are forced to delay their plans when the campus is terrorized by a mysterious creature known as Char Gar Gothakon, whose screams can destroy anything in its path. With the help of Professor Harlan Ellison and Professor H.P. Hatecraft, they manage to find out why the creature is after Professor Hatecraft. After catching Char Gar Gothakon, the gang reunites only to find that Mr. E has left them a box belonging to the Darrow family, along with a note which reads that the old Mystery Incorporated might never have disappeared if they had this box in their possession. Upon opening the box, its contents are revealed to be an entire history of Crystal Cove. Velma states that it seems that one mystery has now become two.