Weasel and I.R. investigate to see who has done the heinous crime of erasing Cow and Chicken out of existence. Eventually they discover that the culprit is the Red Guy trying to take over the show, and this was all a dream Cow had.
Both Weasel and I.R. end up in hospital after a collision course. However, a slight mix-up in the operation room leads to both having the other’s brain. This episode was originally meant to be the series finale, but the show was renewed for a second season.